Phyto Compounds

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A new polysaccharide from Dendrobium officinale reported to have a high intestinal immunomodulating activity

Bioactivity-guided sequential isolation procedure based on the screening of Peyer's patch-mediated immunomodulating activity was adopted to obtain a homogeneous polysaccharide fraction (DOP-W3-b) from the stems of Dendrobium officinale. Oral administration experiments of mice showed that DOP-W3-b could effectively regulate intestinal mucosal immune activity by changing intestinal mucosal structures, promoting the secretions of cytokines from Peyer's patches (PPs) and mesenteric lymph nodes (MLNs), and increasing the production of secretory immunoglobulin A (sIgA) in the lamina propria. Structure analysis indicated that DOP-W3-b was composed of mannose and glucose in a molar ratio of 4.5 with a relatively low molecular weight of 1.543 × 104 Da, and its repeat unit contained a backbone consisting of β-(1→4)-d-Manp, β-(1→4)-d-Glcp and β-(1→3,6)-d-Manp residues, a branch consisting of β-(1→4)-d-Manp, β-(1→4)-d-Glcp and terminal β-d-Glcp, and O-acetyl groups attached to O-2 of β-(1→4)-d-Manp. These results suggested that DOP-W3-b was a new polysaccharide with an essential potential for modulating body's immune functions.


Bacosides A and B -cytogenetic effect on cultured human lymphocytes

Bacosides A and B were isolated from the total methanol extract of Bacopa monnieri. They were evaluated for their in vitro cytogenetic effects on human peripheral blood lymphocytes by chromosomal aberration (CA) assay and sister chromatid exchange (SCE) assay. The frequency of chromatid type aberrations and reciprocal interchanges between sister chromatids in the treated cells was scored in comparison to the untreated control. Results of this study reveal that at 30 μg/mL dose, Bacoside A  showed a statistically significant increase in the frequency of both CA and SCE and Bacoside B showed an increase only in SCE assay.  

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