Phyto Compounds

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Bacosides A and B -cytogenetic effect on cultured human lymphocytes

Bacosides A and B were isolated from the total methanol extract of Bacopa monnieri. They were evaluated for their in vitro cytogenetic effects on human peripheral blood lymphocytes by chromosomal aberration (CA) assay and sister chromatid exchange (SCE) assay. The frequency of chromatid type aberrations and reciprocal interchanges between sister chromatids in the treated cells was scored in comparison to the untreated control. Results of this study reveal that at 30 μg/mL dose, Bacoside A  showed a statistically significant increase in the frequency of both CA and SCE and Bacoside B showed an increase only in SCE assay.  

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